… of many 60S ribosomal proteins also activated Pdr1, thus mimicking the effects of the mRNA
… results of genome-wide screens for genes influencing fluconazole resistance in pdr1∆ and …

… data we analysed the genome-wide dysregulation of protein … share a TF-binding motif
recognised by Pdr1 and Pdr3 [56]. In the S… of transcriptional activation in multidrug resistance …

… CRISPR-based, genome-wide knockout and knockdown … Recently, a selection with rapamycin
in a pdr1 deletion strain of … SNVs lead to constitutive transcriptional activation of its target …

… a diversity of transcriptional activators to achieve robust gene … been applied in fungal pathogens
and other fungal species. In C. … were due to transcriptional overexpression of PDR1, we …

… data we analysed the genome-wide dysregulation of protein … a TF-binding motif recognized
by Pdr1 and Pdr3 [45]. In the S… that acts predominantly as a transcriptional activator [44, 47, 48…

… The pathogenic yeast Candida glabrata acquires resistance … forms of Pdr1 have elevated
transcriptional activation, we … with a PCR fragment containing three copies of human influenza …

… CRISPR-based, genome-wide knockout and knockdown … SNVs lead to constitutive
transcriptional activation of their target … PDR3, a new yeast regulatory gene, is homologous to …

… CRISPRi screens can therefore be truly genome wide, as … to fungal pathogens, utilizing
different transcriptional activators … -fold increase in PDR1 transcription and subsequent reduction …

… genome-wide transcriptional profiling for a large subset of 35 ZCF gain-of-function mutants
(GOF) to elucidate the transcriptional … function of some specific ZCFs in the fungal pathogen. …

… a resistant clinical isolate, mimicking clinical azole failure. The … can perform the first
genome-wide forward genetic screen in … of yeast PDR1 mutants that show hyperactive …